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Review Article

紫檀二苯乙烯对糖尿病、肝脏脂肪变性和血脂的影响

卷 28, 期 2, 2021

发表于: 29 October, 2019

页: [238 - 252] 页: 15

弟呕挨: 10.2174/0929867326666191029112626

价格: $65

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摘要

紫檀二苯乙烯是一种从白藜芦醇中提取的酚类化合物，由于存在两个甲氧基，因此比其母体化合物具有更大的生物利用度。本文就紫檀芪对糖尿病、肝脏脂肪变性和血脂异常的治疗作用进行综述。紫檀二苯乙烯是一种有效的预防1型糖尿病、胰岛素抵抗和2型糖尿病动物模型的生物活性化合物。在1型糖尿病中，证实该酚类化合物具有积极作用的主要机制是提高肝糖原含量和肝脏葡萄糖激酶和磷酸果糖激酶活性，恢复胰岛结构，细胞保护，降低血清和胰腺促炎细胞因子。据报道，2型糖尿病患者肝脏葡萄糖激酶和葡萄糖-6-磷酸酶升高，果糖-1,6-二磷酸酶活性降低。当饮食引起胰岛素抵抗时，胰岛素信号级联的激活程度更高，心肌营养因子-1水平升高，肝脏葡萄糖激酶和葡萄糖- 6-磷酸酶活性升高，果糖-1,6-二磷酸酶活性降低。迄今为止关于紫檀芪和肝脏脂肪变性的资料很少，但氧化应激的减少可能与紫檀芪引起的氧化应激有关，因为氧化应激与脂肪变性向脂肪性肝炎的进展有关。最后，紫檀二苯乙烯有效降低血脂异常动物模型的总胆固醇、ldl -胆固醇和血清甘油三酯水平，升高hdl -胆固醇水平。

关键词: 紫檀二苯乙烯，血糖控制，胰岛素抵抗，糖尿病，血脂异常，肝脏脂肪变性，非酒精性脂肪性肝病。

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