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Recent Patents on Drug Delivery & Formulation

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ISSN (Print): 1872-2113
ISSN (Online): 2212-4039

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Review Article

Recent Patents Concerning the use of Nanotechnology-based Delivery Systems as Skin Penetration Enhancers

Author(s): Bruna Medeiros-Neves, Marina Cardoso Nemitz, Flávia Nathiely Silveira Fachel and Helder Ferreira Teixeira*

Volume 13, Issue 3, 2019

Page: [192 - 202] Pages: 11

DOI: 10.2174/1872211313666191024112137

Open Access Journals Promotions 2
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Abstract

Nanotechnology-based delivery systems have been considered a promising approach for topical application, considering their characteristics of penetration into/across the skin. The present review aimed to evaluate the recent international scenario of patents concerning the use of nanotechnology- based delivery systems as skin penetration enhancers. A survey of recent patent documents was conducted by using the Espacenet patent database including the terms “skin” in the title and “promot* or enhanc* and penetrat* or absorp* or permeat*” and “nano*” with the truncation symbol (*) in the abstract of documents. A total of 110 patents were published from 2008 to 2018, with 94 technologies being considered. The results demonstrated an increase in innovations concerning nanotechnologybased delivery systems as skin penetration enhancers in recent years. Most patent applicants are from China (60.6%) and Korea (21.3%), and companies (68%) were the most prominent owners. The majority of patent applications (76%) were intended for cosmetic purposes; the types of products and nanostructures were also investigated. Overall results demonstrated the increased interest around the world in patenting products involving skin permeation promotion and nanotechnology for pharmaceutical and, mainly, for cosmetics purposes.

Keywords: Nanotechnology-based delivery systems, patents, penetration enhancers, skin delivery, cosmetic purposes, nanostructures.

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[1]
Cosco D, Celia C, Cilurzo F, Trapasso E, Paolino D. Colloidal carriers for the enhanced delivery through the skin. Expert Opin Drug Deliv 2008; 5(7): 737-55.
[http://dx.doi.org/10.1517/17425247.5.7.737] [PMID: 18590459]
[2]
Mota AH, Rijo P, Molpeceres J, Reis CP. Broad overview of engineering of functional nanosystems for skin delivery. Int J Pharm 2017; 532(2): 710-28.
[http://dx.doi.org/10.1016/j.ijpharm.2017.07.078] [PMID: 28764984]
[3]
Lane ME. Skin penetration enhancers. Int J Pharm 2013; 447(1-2): 12-21.
[http://dx.doi.org/10.1016/j.ijpharm.2013.02.040] [PMID: 23462366]
[4]
Yotsumoto K, Ishii K, Kokubo M, Yasuoka S. Improvement of the skin penetration of hydrophobic drugs by polymeric micelles. Int J Pharm 2018; 553(1-2): 132-40.
[http://dx.doi.org/10.1016/j.ijpharm.2018.10.039] [PMID: 30339944]
[5]
Amjadi M, Mostaghaci B, Sitti M. Recent advances in skin penetration enhancers for transdermal gene and drug delivery. Curr Gene Ther 2017; 17(2): 139-46.
[http://dx.doi.org/10.2174/1566523217666170510151540] [PMID: 28494734]
[6]
Souto EB, Doktorovova S, Boonme P. Lipid-based colloidal systems (nanoparticles, microemulsions) for drug delivery to the skin: Materials and end-product formulations. J Drug Deliv Sci Technol 2011; 21: 43-54.
[http://dx.doi.org/10.1016/S1773-2247(11)50005-X]
[7]
Souto EB, Müller RH. Cosmetic features and applications of lipid nanoparticles (SLN, NLC). Int J Cosmet Sci 2008; 30(3): 157-65.
[http://dx.doi.org/10.1111/j.1468-2494.2008.00433.x] [PMID: 18452432]
[8]
Lane ME. Nanoparticles and the skin- Applications and limitations. J Microencapsul 2011; 28(8): 709-16.
[http://dx.doi.org/10.3109/02652048.2011.599440] [PMID: 21767116]
[9]
Sala M, Diab R, Elaissari A, Fessi H. Lipid nanocarriers as skin drug delivery systems: Properties, mechanisms of skin interactions and medical applications. Int J Pharm 2018; 535(1-2): 1-17.
[http://dx.doi.org/10.1016/j.ijpharm.2017.10.046] [PMID: 29111097]
[10]
Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol 2012; 4(3): 308-19.
[http://dx.doi.org/10.4161/derm.22804] [PMID: 23467476]
[11]
Torin HJ, Sivaloganathan S, Kohandel M, Foldvari M. Drug delivery through the skin: Molecular simulations of barrier lipids to design more effective noninvasive dermal and transdermal delivery systems for small molecules, biologics, and cosmetics. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2011; 3(5): 449-62.
[http://dx.doi.org/10.1002/wnan.147] [PMID: 21595050]
[12]
Lademann J, Richter H, Schanzer S, et al. Penetration and storage of particles in human skin: Perspectives and safety aspects. Eur J Pharm Biopharm 2011; 77(3): 465-8.
[http://dx.doi.org/10.1016/j.ejpb.2010.10.015] [PMID: 21056659]
[13]
Vitorino C, Sousa J, Pais A. Overcoming the skin permeation barrier: Challenges and opportunities. Curr Pharm Des 2015; 21(20): 2698-712.
[http://dx.doi.org/10.2174/1381612821666150428124053] [PMID: 25925125]
[14]
Nastiti CMRR, Ponto T, Abd E, Grice JE, Benson HAE, Roberts MS. Topical nano and microemulsions for skin delivery. Pharmaceutics 2017; 9(4): 1-25.
[http://dx.doi.org/10.3390/pharmaceutics9040037] [PMID: 28934172]
[15]
Karadzovska D, Brooks JD, Monteiro-Riviere NA, Riviere JE. Predicting skin permeability from complex vehicles. Adv Drug Deliv Rev 2013; 65(2): 265-77.
[http://dx.doi.org/10.1016/j.addr.2012.01.019] [PMID: 22342772]
[16]
de Matos SP, Teixeira HF, de Lima ÁAN, Veiga-Junior VF, Koester LS. Essential oils and isolated terpenes in nanosystems designed for topical administration: A review. Biomolecules 2019; 9(4): 1-19.
[http://dx.doi.org/10.3390/biom9040138] [PMID: 30959802]
[17]
Alvarez-Román R, Naik A, Kalia YN, Guy RH, Fessi H. Skin penetration and distribution of polymeric nanoparticles. J Control Release 2004; 99(1): 53-62.
[http://dx.doi.org/10.1016/j.jconrel.2004.06.015] [PMID: 15342180]
[18]
Batheja P, Sheihet L, Kohn J, Singer AJ, Michniak-Kohn B. Topical drug delivery by a polymeric nanosphere gel: Formulation optimization and in vitro and in vivo skin distribution studies. J Control Release 2011; 149(2): 159-67.
[http://dx.doi.org/10.1016/j.jconrel.2010.10.005] [PMID: 20950659]
[19]
Ganesan P, Choi DK. Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy. Int J Nanomedicine 2016; 11: 1987-2007.
[http://dx.doi.org/10.2147/IJN.S104701] [PMID: 27274231]
[20]
Gupta M, Agrawal U, Vyas SP. Nanocarrier-based topical drug delivery for the treatment of skin diseases. Expert Opin Drug Deliv 2012; 9(7): 783-804.
[http://dx.doi.org/10.1517/17425247.2012.686490] [PMID: 22559240]
[21]
Fang JY, Hwang TL, Huang YL. Liposomes as vehicles for enhancing drug delivery via skin routes. Curr Nanosci 2006; 2: 55-70.
[http://dx.doi.org/10.2174/157341306775473791]
[22]
Ngwuluka NC, Pillay V, Choonara YE, et al. Fabrication, modeling and characterization of multi-crosslinked methacrylate copolymeric nanoparticles for oral drug delivery. Int J Mol Sci 2011; 12(9): 6194-225.
[http://dx.doi.org/10.3390/ijms12096194] [PMID: 22016653]
[23]
Küchler S, Herrmann W, Panek-Minkin G, et al. SLN for topical application in skin diseases- Characterization of drug-carrier and carrier-target interactions. Int J Pharm 2010; 390(2): 225-33.
[http://dx.doi.org/10.1016/j.ijpharm.2010.02.004] [PMID: 20153414]
[24]
Lin YK, Yang SH, Chen CC, Kao HC, Fang JY. Using imiquimod-induced psoriasis-like skin as a model to measure the skin penetration of anti-psoriatic drugs. PLoS One 2015; 10(9) e0137890
[http://dx.doi.org/10.1371/journal.pone.0137890] [PMID: 26355594]
[25]
Domínguez-Villegas V, Clares-Naveros B, García-López ML, Calpena-Campmany AC, Bustos-Zagal P, Garduño-Ramírez ML. Development and characterization of two nano-structured systems for topical application of flavanones isolated from Eysenhardtia platycarpa. Colloids Surf B Biointerfaces 2014; 116: 183-92.
[http://dx.doi.org/10.1016/j.colsurfb.2013.12.009] [PMID: 24463153]
[26]
Jenning V, Gysler A, Schäfer-Korting M, Gohla SH. Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm 2000; 49(3): 211-8.
[http://dx.doi.org/10.1016/S0939-6411(99)00075-2] [PMID: 10799811]
[27]
Liu J, Hu W, Chen H, Ni Q, Xu H, Yang X. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm 2007; 328(2): 191-5.
[http://dx.doi.org/10.1016/j.ijpharm.2006.08.007] [PMID: 16978810]
[28]
Alomrani AH, Shazly GA, Amara AAAF, Badran MM. Itraconazole-hydroxypropyl-β-cyclodextrin loaded deformable liposomes: In vitro skin penetration studies and antifungal efficacy using Candida albicans as model. Colloids Surf B Biointerfaces 2014; 121: 74-81.
[http://dx.doi.org/10.1016/j.colsurfb.2014.05.030] [PMID: 24937135]
[29]
Marafon P, Fachel FNS, Dal Prá M, et al. Development, physico-chemical characterization and in-vitro studies of hydrogels containing rosmarinic acid-loaded nanoemulsion for topical application. J Pharm Pharmacol 2019; 71(8): 1199-208.
[http://dx.doi.org/10.1111/jphp.13102] [PMID: 31124591]
[30]
Monteiro-Riviere NA, Wiench K, Landsiedel R, Schulte S, Inman AO, Riviere JE. Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: An in vitro and in vivo study. Toxicol Sci 2011; 123(1): 264-80.
[http://dx.doi.org/10.1093/toxsci/kfr148] [PMID: 21642632]
[31]
Abdel-Mottaleb MMA, Moulari B, Beduneau A, Pellequer Y, Lamprecht A. Nanoparticles enhance therapeutic outcome in inflamed skin therapy. Eur J Pharm Biopharm 2012; 82(1): 151-7.
[http://dx.doi.org/10.1016/j.ejpb.2012.06.006] [PMID: 22728016]
[32]
Nemitz MC, Argenta DF, Koester LS, Bassani VL, von Poser GL, Teixeira HF. The international scenario of patents concerning isoflavones. Trends Food Sci Technol 2016; 49: 85-95.
[http://dx.doi.org/10.1016/j.tifs.2016.01.008]
[33]
Ernst H. Patent information for strategic technology management. World Pat Inf 2003; 25: 233-42.
[http://dx.doi.org/10.1016/S0172-2190(03)00077-2]
[34]
Basberg BL. Patents and the measurement of technological change: A survey of the literature. Res Policy 1987; 16: 131-41.
[http://dx.doi.org/10.1016/0048-7333(87)90027-8]
[35]
Noh H, Jo Y, Lee S. Keyword selection and processing strategy for applying text mining to patent analysis. Expert Syst Appl 2015; 42: 4348-60.
[http://dx.doi.org/10.1016/j.eswa.2015.01.050]
[36]
Napoleão de RB. Systematic x Narrative Review. Acta Paul Enferm 2007; 20(2): 6-7.
[37]
Frietsch R, Schmoch U, van Looy B, et al. The value and indicator function of patents. Stud Zum Dtsch Innov 2011; 40: 969-85.
[38]
Idris K. Intellectual property: A power tool for economic growth. World Pat Inf 2003; 25: 359-60.
[http://dx.doi.org/10.1016/S0172-2190(03)00075-9]
[39]
Roberts MS, Mohammed Y, Pastore MN, et al. Topical and cutaneous delivery using nanosystems. J Control Release 2017; 247: 86-105.
[http://dx.doi.org/10.1016/j.jconrel.2016.12.022] [PMID: 28024914]
[40]
World Intellectual Property Indicators 2018 World Intellect Prop Organ 2018.
[41]
Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products. Off J. Eur Union 2009; 2009: 342-59.
[42]
Yapar EA. Intellectual property and patent in cosmetics. Marmara Pharm J 2017; 21: 419-24.
[http://dx.doi.org/10.12991/marupj.306786]
[43]
Galenytska K. Euromonitor Consumer Trends 2019; 2019: 21.
[44]
Łopaciuk A, Łoboda M. Global Beauty Industry Trends in the 21st Century. Active Citizenship by Knowledge Management & Innovation: Proceedings of the Management Knowledge and Learning International Conference 2013.
[45]
Bom S, Jorge J, Ribeiro HM, Marto J. A step forward on sustainability in the cosmetics industry: A review. J Clean Prod 2019; 225: 270-90.
[http://dx.doi.org/10.1016/j.jclepro.2019.03.255]
[46]
Thoma G. Trademarks and the patent premium value: Evidence from medical and cosmetic products. World Pat Inf 2015; 41: 23-30.
[http://dx.doi.org/10.1016/j.wpi.2015.02.003]
[47]
Global Beauty & Personal Care Trends. 2018.
[48]
Loo Ch, Basri M, Ismail R, et al. Effect of compositions in Nanostructured Lipid Carriers (NLC) on skin hydration and occlusion. Int J Nanomedicine 2013; 8: 13-22.
[PMID: 23293516]
[49]
Kong M, Chen XG, Kweon DK, Park HJ. Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier. Carbohydr Polym 2011; 86: 837-43.
[http://dx.doi.org/10.1016/j.carbpol.2011.05.027]
[50]
Budhiraja A, Dhingra G. Development and characterization of a novel antiacne niosomal gel of rosmarinic acid. Drug Deliv 2015; 22(6): 723-30.
[http://dx.doi.org/10.3109/10717544.2014.903010] [PMID: 24786487]
[51]
Balestrin LA, Bidone J, Bortolin RC, Moresco K, Moreira JC, Teixeira HF. Protective effect of a hydrogel containing Achyrocline satureioides extract-loaded nanoemulsion against UV-induced skin damage. J Photochem Photobiol B 2016; 163: 269-76.
[http://dx.doi.org/10.1016/j.jphotobiol.2016.08.039] [PMID: 27599114]
[52]
Back PI, Furtado LR, Nemitz MC, et al. Skin permeation and oxidative protection effect of soybean isoflavones from topical nanoemulsions. A comparative study of extracts and pure compounds. AAPS PharmSciTech 2018; 19(7): 3029-39.
[http://dx.doi.org/10.1208/s12249-018-1133-x] [PMID: 30084071]
[53]
Frombach J, Unbehauen M, Kurniasih IN, et al. Core-multishell nanocarriers enhance drug penetration and reach keratinocytes and antigen-presenting cells in intact human skin. J Control Release 2019; 299: 138-48.
[http://dx.doi.org/10.1016/j.jconrel.2019.02.028] [PMID: 30797867]
[54]
Mahmoud NN, Alkilany AM, Dietrich D, Karst U, Al-Bakri AG, Khalil EA. Preferential accumulation of gold nanorods into human skin hair follicles: Effect of nanoparticle surface chemistry. J Colloid Interface Sci 2017; 503: 95-102.
[http://dx.doi.org/10.1016/j.jcis.2017.05.011] [PMID: 28502717]
[55]
Zhang H, Zhai Y, Yang X, Zhai G. Breaking the skin barrier: Achievements and future directions. Curr Pharm Des 2015; 21(20): 2713-24.
[http://dx.doi.org/10.2174/1381612821666150428124406] [PMID: 25925124]
[56]
Steinbach O. An industry update: The latest developments in therapeutic delivery covering February 2019. Ther Deliv 2019; 10(6): 337-41.
[http://dx.doi.org/10.4155/tde-2019-0023] [PMID: 31161890]
[57]
Ren T, Yang X, Wu N, Cai Y, Liu Z, Yuan W. Sustained-release formulation of levodopa methyl ester/benserazide for prolonged suppressing dyskinesia expression in 6-OHDA-leisoned rats. Neurosci Lett 2011; 502(2): 117-22.
[http://dx.doi.org/10.1016/j.neulet.2011.07.042] [PMID: 21835223]
[58]
Nemitz MC, Moraes RC, Koester LS, Bassani VL, von Poser GL, Teixeira HF. Bioactive soy isoflavones: Extraction and purification procedures, potential dermal use and nanotechnology-based delivery systems. Phytochem Rev 2014; 14: 849-69.
[http://dx.doi.org/10.1007/s11101-014-9382-0]
[59]
Al-Subaie MM, Hosny KM, El-Say KM, Ahmed TA, Aljaeid BM. Utilization of nanotechnology to enhance percutaneous absorption of acyclovir in the treatment of herpes simplex viral infections. Int J Nanomedicine 2015; 10: 3973-85.
[PMID: 26109856]
[60]
de Vargas BA, Bidone J, Oliveira LK, Koester LS, Bassani VL, Teixeira HF. Development of topical hydrogels containing genistein-loaded nanoemulsions. J Biomed Nanotechnol 2012; 8(2): 330-6.
[http://dx.doi.org/10.1166/jbn.2012.1386] [PMID: 22515085]
[61]
Bidone J, Argenta DF, Kratz J, et al. Antiherpes activity and skin/mucosa distribution of flavonoids from Achyrocline satureioides extract incorporated into topical nanoemulsions. BioMed Res Int 2015; 2015 238010
[http://dx.doi.org/10.1155/2015/238010] [PMID: 26101767]
[62]
Zheng L, Gong Z, Lu Y, et al. A UPLC-MS/MS method for simultaneous determination of danshensu, protocatechuic aldehyde, rosmarinic acid, and ligustrazine in rat plasma, and its application to pharmacokinetic studies of Shenxiong glucose injection in rats. J Chromatogr B Analyt Technol Biomed Life Sci 2015; 997: 210-7.
[http://dx.doi.org/10.1016/j.jchromb.2015.06.008] [PMID: 26118621]
[63]
Akhtar N, Verma A, Pathak K. Topical delivery of drugs for the effective treatment of fungal infections of skin. Curr Pharm Des 2015; 21(20): 2892-913.
[http://dx.doi.org/10.2174/1381612821666150428150456] [PMID: 25925110]
[64]
European Commission Recommendation of 18 October 2011 on the definition of nanomaterial, 2011/696/EU. Off J. Eur Union 2011; 2011: 54.
[65]
Pulit-Prociak J, Grabowska A, Chwastowski J, Majka TM, Banach M. Safety of the application of nanosilver and nanogold in topical cosmetic preparations. Colloids Surf B Biointerfaces 2019; 183(1)110416
[http://dx.doi.org/10.1016/j.colsurfb.2019.110416] [PMID: 31398622]
[66]
Contado C. Nanomaterials in consumer products: A challenging analytical problem. Front Chem 2015; 3: 48.
[http://dx.doi.org/10.3389/fchem.2015.00048] [PMID: 26301216]
[67]
Hughes GA. Nanostructure-mediated drug delivery. Nanomedicine Nanotechnol Biol Medi 2005; 1: 22-30.
[68]
Singh Y, Meher JG, Raval K, et al. Nanoemulsion: Concepts, development and applications in drug delivery. J Control Release 2017; 252: 28-49.
[http://dx.doi.org/10.1016/j.jconrel.2017.03.008] [PMID: 28279798]
[69]
Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: An advanced mode of drug delivery system. 3 Biotech 2015; 5: 123-7.
[70]
Thakur N, Garg G, Sharma PK, Kumar N. Nanoemulsions: A review on various pharmaceutical application. Glob J Pharmacol 2012; 6: 222-5.
[71]
Sheoran R, Khokra SL, Chawla V, Dureja H. Recent patents, formulation techniques, classification and characterization of liposomes. Recent Pat Nanotechnol 2019; 13(1): 17-27.
[http://dx.doi.org/10.2174/1872210513666181127110413] [PMID: 30479223]
[72]
Akbarzadeh A, Rezaei-Sadabady R, Davaran S, et al. Liposome: Classification, preparation, and applications. Nanoscale Res Lett 2013; 8(1): 102.
[http://dx.doi.org/10.1186/1556-276X-8-102] [PMID: 23432972]
[73]
Frank LA, Contri RV, Beck RCR, Pohlmann AR, Guterres SS. Improving drug biological effects by encapsulation into polymeric nanocapsules. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2015; 7(5): 623-39.
[http://dx.doi.org/10.1002/wnan.1334] [PMID: 25641603]
[74]
Mora-Huertas CE, Fessi H, Elaissari A. Polymer-based nanocapsules for drug delivery. Int J Pharm 2010; 385(1-2): 113-42.
[http://dx.doi.org/10.1016/j.ijpharm.2009.10.018] [PMID: 19825408]
[75]
Crespy D, Lv LP, Landfester K. Redefining the functions of nanocapsule materials. Nanoscale Horizons 2016; 1: 268-71.
[http://dx.doi.org/10.1039/C5NH00112A]
[76]
Baimanov D, Cai R, Chen C. Understanding the chemical nature of nanoparticle-protein interactions. Bioconjug Chem 2019; 30(7): 1923-37.
[http://dx.doi.org/10.1021/acs.bioconjchem.9b00348] [PMID: 31259537]
[77]
Choi WI, Lee JH, Kim JY, Kim JC, Kim YH, Tae G. Efficient skin permeation of soluble proteins via flexible and functional nano-carrier. J Control Release 2012; 157(2): 272-8.
[http://dx.doi.org/10.1016/j.jconrel.2011.08.013] [PMID: 21867735]
[78]
Verma D, Gulati N, Kaul S, Mukherjee S, Nagaich U. Protein based nanostructures for drug delivery. J Pharm 2018; 2018 9285854
[http://dx.doi.org/10.1155/2018/9285854] [PMID: 29862118]

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