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Research Article

TRIM45抑制非小细胞肺癌的发展

卷 20, 期 4, 2020

页: [299 - 306] 页: 8

弟呕挨: 10.2174/1566524019666191017143833

价格: $65

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摘要

背景：以前，我们首先确定了包含人三方基序的蛋白45（TRIM45）在有丝分裂原激活的蛋白激酶（MAPK）信号传导途径中起着新的转录阻遏物的作用。此后，TRIM45在肿瘤发展中的抑制作用逐渐显现。然而，TRIM45在肺癌的肿瘤发生中的功能尚未被表征。 方法和结果：在这项研究中，我们发现TRIM45在早期人类非小细胞肺癌（NSCLC）组织中上调。 TRIM45在肺癌细胞中的过表达诱导G1阻滞并促进细胞凋亡，并伴有RB，p16，p53，p27Kip1和Caspase3的表达上调以及CyclinE1和CyclinE2的表达下调。 MAPK信号通路中分子表达的进一步检测表明，肺癌细胞中TRIM45的过表达促进了磷酸化的p38（p-p38）活化并抑制了磷酸化的ERK（p-ERK）活化。据此，在肺癌组织中p-p38增加而p-ERK减少。 结论：这些发现表明TRIM45在肺癌的肿瘤发生中具有抑制作用。 TRIM45在肺癌组织中的高表达可能通过激活p38信号促进细胞凋亡，并通过下调p-ERK抑制增殖，为理解肺癌的发生提供了新的线索。

关键词: TRIM45，NSCLC，肺癌，细胞凋亡，抑制作用，MAPK途径。

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