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Review Article

天然存在的化合物通过靶向NFATc1相关的信号通路抑制破骨细胞生成

卷 21, 期 4, 2020

页: [358 - 364] 页: 7

弟呕挨: 10.2174/1389450120666191017121610

价格: $65

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摘要

破骨细胞起源于造血谱系的单核细胞前体。 转录因子对基因表达的调控是控制细胞功能的主要机制之一。 这在破骨细胞生产过程中特别重要。 作为主要的调控转录因子，活化的T细胞胞质1（NFATc1）的核因子在破骨细胞分化中起着重要作用。 尽管当前的研究集中在破骨细胞形成过程中治疗的调节作用上，但许多这类药物具有对骨形成有害的细胞毒性。 在目前的临床和基础研究中，最需要具有很少或没有副作用的天然存在的化合物。 在本文中，我们总结了几种植物来源的化合物在抑制破骨细胞形成中的作用。

关键词: 破骨细胞，NFATc1，天然化合物，信号传导途径。

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