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Review Article

靶向RANKL信号通路的天然化合物治疗骨病的研究

卷 21, 期 4, 2020

页: [344 - 357] 页: 14

弟呕挨: 10.2174/1389450120666190930145144

价格: $65

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摘要

数以百万计的人，特别是针对老年人，正遭受类风湿性关节炎（RA）和骨质疏松症等骨质流失疾病的折磨。因此，需要进一步了解骨代谢的相关机制，以进一步治疗此类疾病。特别是在骨丢失的病理过程中，RANKL作为肿瘤坏死因子（TNF）超家族的一员，可以诱导破骨细胞前体细胞分化为成熟的破骨细胞，从而在破骨过程中发挥重要作用。近年来，随着对天然化合物发现研究的日益关注，天然植物衍生物的治疗应用已得到广泛认可。因此，我们目前的研究旨在总结RANKL及其下游信号通路在骨细胞分化中的最新研究进展，并为RANKL作为骨丢失疾病的重要药物靶点提供进一步的认识。除此之外，在我们目前的研究中，我们还旨在简要介绍几种天然化合物通过调节RANKL信号通路来治疗RANKL介导的破骨细胞活化的应用及其对预防骨质疏松症，骨关节炎（OA）和RA的治疗作用。

关键词: RANKL，NF-κB，MAPK，Akt，Ca2 +，骨质疏松症，骨关节炎，类风湿关节炎，信号通路。

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