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Mini-Review Article

Molecular and Biological Functions of Melatonin in Endometrial Cancer

Author(s): Parisa Maleki Dana, Fatemeh Sadoughi, Moein Mobini, Rana Shafabakhsh, Shala Chaichian*, Bahram Moazzami, Maryam Chamani and Zatollah Asemi*

Volume 21, Issue 5, 2020

Page: [519 - 526] Pages: 8

DOI: 10.2174/1389450120666190927123746

Price: $65

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Abstract

Endometrial cancer is the fifth leading cancer among women. This rate is higher in developed countries and its incidence is increasing worldwide. Diabetes mellitus, obesity, hypertension and arteriosclerosis are major risk factors for endometrial cancer. Melatonin is a hormone synthesized in the pineal and extra-pineal organs such as the digestive tract, bone marrow, retina and more. Evidence shows the potential effects of melatonin in endometrial cancer inhibition. Therefore, the focus of this paper is to review this outstanding evidence and to summarize the molecular and biological mechanisms of melatonin for the inhibition of endometrial cancer.

Keywords: Melatonin, pregnancy, endometrial cancer, apoptosis, obesity, bone marrow.

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