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Review Article

内皮在过早的动脉粥样硬化中的作用：分子机制。

卷 27, 期 7, 2020

页: [1041 - 1051] 页: 11

弟呕挨: 10.2174/0929867326666190911141951

价格: $65

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摘要

动脉粥样硬化疾病仍然是死亡的主要原因之一。动脉粥样硬化是一种复杂的进行性和系统性动脉疾病，涉及大，中动脉血管的内膜。炎症在该疾病的病理生理过程中起关键作用，内膜从单核细胞，巨噬细胞和T淋巴细胞的浸润与内皮功能障碍和累积的氧化型低密度脂蛋白（LDL）结合是动脉粥样硬化的主要发现。动脉粥样硬化的发展涉及多种遗传和环境因素。尽管已经在与动脉粥样硬化有关的染色体区域中鉴定出大量基因，遗传多态性和易感基因座，但是调节表皮组织和基因表达的表观遗传过程在动脉粥样硬化的发病机理中起着至关重要的作用。尽管在了解动脉粥样硬化的发病机理方面取得了积极进展，但对该疾病的了解仍然很少。

关键词: E内皮，内皮功能障碍，分子，心血管疾病，动脉粥样硬化，系统性动脉疾病。

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